Stimulant laxatives (including Senokot Syrup Pharmacy) do not help with weight loss. They do not reduce the absorption of calories or nutrients. They can cause watery stools (diarrhoea), abdominal cramps and dehydration. Dehydration can seem like weight loss.

An extract and aloe-emodin were mutagenic in in vitro tests, sennoside A, B and rhein gave negative results. Comprehensive in vivo examinations of a defined extract of senna pods were negative. In addition a specified senna extract given orally for 2 years was not carcinogenic in male or female rats. The extract investigated contained approximately 40.8% of anthranoids from which 35% were sennosides, corresponding to about 25.2% of potential rhein, 2.3% of potential aloe-emodin and 0.007% of potential emodin and 142 ppm free aloe-emodin and 9 ppm free emodin. The Senokot Family of Laxatives includes a solution that's right for virtually every member of your family. Choose Senokot Tablets, or, if constipation is accompanied by hard, dry stools, choose dual-action Senokot-S Tablets with docusate sodium to hydrate and soften hard, dry stools.

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Yellow or red-brown (pH dependent) discolouration of urine by metabolites, which is not clinically significant, may occur during the treatment.

If the symptoms persist during the use of the medicinal product, a doctor or a pharmacist should be consulted. For over 45 years, families like yours have relied on the Natural Vegetable Laxative Ingredient in Senokot to provide overnight relief from their occasional constipation. Senokot Laxative Products work gently and have become a reliable and reputable brand. It's the senna laxative ingredient that's been documented in over 8,000 patients and over 50 clinical studies. in particular in patients with irritable colon. Symptoms may also occur generally as a consequence of individual overdosage. In such cases dose reduction is necessary.There was no evidence of any embryolethal, teratogenic or foetotoxic actions in rats or rabbits after oral treatment with sennosides. Furthermore, there was no effect on the postnatal development of young rats, on rearing behaviour of dams or on male and female fertility in rats. Data for herbal preparations are not available. Chronic use may cause pigmentation of the intestinal mucosa (pseudomelanosis coli), which usually recedes when the patient stops taking the preparation. Senna syrup comes with a plastic cup or spoon to measure the dose. Do not use a kitchen spoon as it will not measure the right amount. How to take it In a 90-day rat study, senna pods were administered at dose levels from 100 mg/kg up to 1,500 mg/kg. The tested drug contained 1.83 % sennosides A-D, 1.6 % potential rhein, 0.11 % potential aloe-emodin and 0.014 % potential emodin. In all groups epithelial hyperplasia of the large intestine of minor degree was found and was reversible within the 8-week recovery period. The hyperplastic lesions of the forestomach epithelium were reversible as well. Dose-dependent tubular basophilia and epithelial hypertrophy of the kidneys were seen at a dose of, or greater than 300 mg/kg per day without functional affection. These changes were also reversible. Storage of a brown tubular pigment led to a dark discoloration of the renal surface and still remained to a lesser degree after the recovery period. No alterations were seen in the colonic nervous plexus. A no-observable-effect-level (NOEL) could not be obtained in this study. Senokot tablets, syrup and granules contain Senna, a natural plant extract which works by stimulating the muscles in the bowel in a similar way to figs and prunes. Helping to bring gentle, predictable relief. Senokot works with your body, leaving you feeling much fresher and brighter again.

This product should only be used if a therapeutic effect cannot be achieved by a change of diet or the administration of bulk forming agents.

If no bowel action has occurred after three days of progressively increased dosage, a medical examination should be considered.